Publications by authors named "D Alexandre"
Lung cancer (LC) is recognized as one of the most prevalent and lethal cancers worldwide, underscoring an urgent need for innovative diagnostic and therapeutic approaches. MicroRNAs (miRNAs) have emerged as promising biomarkers for several diseases and their progression, such as LC. However, traditional methods for detecting and quantifying miRNAs, such as PCR, are time-consuming and expensive.
View Article and Find Full Text PDFClinical characteristics associated with functioning trajectories following admission to a psychiatric institution: A prospective cohort study of individuals with psychosis.
Psychiatry Res
September 2024
Article Synopsis
- Psychotic disorders can hinder recovery, making functional improvement challenging after hospitalization, which is a critical time for intervention.
- A study analyzed 453 individuals with acute psychosis over a year to explore factors affecting functional recovery, identifying three groups: “improving,” “stable,” and “worsening” function.
- Notably, those starting with more severe symptoms tended to improve function over time, and while the "improving" and "stable" groups showed lasting psychiatric symptoms improvements, the "worsening" group’s initial gains did not sustain.
- These findings suggest that focusing on functional recovery is crucial, rather than just preventing relapses.
Pain and disability were related to Y-balance test but not with proprioception acuity and single-leg triple-hop test in patients with patellofemoral pain: A cross-sectional study.
J Bodyw Mov Ther
April 2024
Article Synopsis
- Patellofemoral pain is common among active individuals, impacting daily activities and possibly impairing movement due to altered proprioception.
- The study included 48 patients, focusing on the relationship between their pain intensity, duration, disability, proprioception (measured through joint position sense), and physical performance in specific tests.
- Results showed that while pain and disability affected balance performance (Y-Balance Test), they did not correlate with proprioceptive acuity or performance in the Single-Leg Triple-Hop Test.
Lung cancer (LC) is a leading cause of global cancer-related deaths, highlighting the development of innovative methods for biomarker detection improving the early diagnostics. microRNAs (miRs) alterations are known to be involved in the initiation and progression of human cancers and can act as biomarkers for diagnostics and treatment. Herein, we develop the application of molecular beacon (MB) technology to monitor miR-155-3p expression in human lung adenocarcinoma A549 cells without complementary DNA synthesis, amplification, or expensive reagents.
View Article and Find Full Text PDFAntibiotics from sulfonamide, fluoroquinolone, and diaminopyrimidine classes are widely used in human and veterinary medicine, and their combined occurrence in the aquatic environment is increasing around the world. In parallel, the understanding of how mixtures of these compounds affect non-target species from tropical freshwaters is scarce. Thus, this work aimed to study the long-term reproductive, recovery, and swimming effects of mixtures of 12 antibiotics from three different classes (up to 10 μg L ) added to freshwater (FWM) and synthetic wastewater (SWM) matrices on freshwater worm Allonais inaequalis.
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