Publications by authors named "D Aleshkina"
Article Synopsis
- Mammalian oocyte development relies on precise translation of maternal mRNA during critical phases of meiotic and early embryonic stages when transcription stops.
- The protein cytoplasmic polyadenylation element-binding protein 3 (CPEB3) plays a crucial role by stabilizing specific mRNAs needed for embryonic transcription.
- Without CPEB3, oocytes can undergo meiosis but face early embryonic development issues due to disrupted mRNA stability, leading to protein expression problems and failed embryonic transcription initiation.
The translational oscillation in oocyte and early embryo development.
Nucleic Acids Res
December 2023
Article Synopsis
- Translation is essential for development, particularly during the silenced transcription phase of oocytes and early embryos.
- A genome-wide translatome analysis revealed that while global protein synthesis decreases during M-phases, the initiation and elongation of translation are activated, showing a dynamic shift in how specific mRNAs are translated.
- This study provides new insights into gene expression regulation during oocyte meiosis and the first two embryonic mitoses, marking a significant step towards understanding the molecular mechanisms of translation control in early development.
Article Synopsis
- Akt (protein kinase B) is crucial in the PI3K/Akt signaling pathway, which controls cell survival, metabolism, and growth.
- It phosphorylates various substrates that manage processes like nuclear envelope breakdown, chromosome segregation, and cytokinesis.
- The review also discusses Akt's role in mRNA translation regulation, particularly in early development stages such as oogenesis and embryo formation.
Article Synopsis
- Cells use various proteins to regulate their division, ensuring the process goes smoothly with checkpoints in place.
- Polo-like kinase 1 (PLK1) is a crucial protein that influences important stages in the cell cycle, like nuclear envelope breakdown and chromosome separation.
- PLK1 also plays a role in regulating the translation of specific mRNAs by inhibiting a repressor, but more research is needed to fully understand its function in meiosis.
Article Synopsis
- * The maturation-promoting factor (MPF), made up of CDK1 and Cyclin B1, is crucial for resuming meiosis, but the mechanisms behind its activation are not fully understood.
- * This study identifies SGK1, a specific kinase expressed in mouse oocytes, as a key player that influences CDK1 activation; inhibiting SGK1 delays meiotic progression, but introducing active CDK1 can reverse this effect, shedding light on how meiosis is regulated.