Publications by authors named "D Adlam"
Background: Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.
Methods: Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls.
Background: Type 2 diabetes (T2D) leads to cardiovascular remodeling, and heart failure has emerged as a major complication of T2D. There is a limited understanding of the impact of T2D on the right heart. This study aimed to assess subclinical right heart alterations and their contribution to aerobic exercise capacity (peak oxygen consumption; peak VO) in adults with T2D.
View Article and Find Full Text PDFBackground: Aerobic exercise capacity is an independent predictor of mortality in dilated cardiomyopathy (DCM), but the central mechanisms contributing to exercise intolerance in DCM are unknown. The aim of this study was to characterize coronary microvascular function in DCM and determine if cardiovascular magnetic resonance (CMR) measures are associated with aerobic exercise capacity.
Methods: Prospective case-control comparison of adults with DCM and matched controls.
Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine Coronary Computed Tomography Angiography.
Eur Heart J Qual Care Clin Outcomes
September 2024
Aims: Coronary Computed Tomography Angiography (CCTA) is a first line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We assessed the lifetime cost-effectiveness of integrating a novel artificial intelligence-enhanced image analysis algorithm (AI-Risk) that stratifies the risk of cardiac events by quantifying coronary inflammation, combined with the extent of coronary artery plaque and clinical risk factors, by analysing images from routine CCTA.
View Article and Find Full Text PDFArticle Synopsis
- A recent meta-analysis found that routine veno-arterial ECMO (VA-ECMO) does not improve outcomes for patients with acute myocardial infarction-related cardiogenic shock (AMI-CS), while a specific microaxial flow pump did lower mortality in a certain patient group.
- Individual patient data from four randomized trials were analyzed, focusing on patients similar to those in the DanGer-Shock trial, which aimed at understanding the 180-day all-cause mortality rates with VA-ECMO.
- Despite a numerically lower 6-month mortality rate with VA-ECMO (45% vs. 51% in control), the risks of major bleeding and peripheral vascular complications were higher, suggesting no clear mortality benefit in this population.