Publications by authors named "D Adam Lauver"
Article Synopsis
- * The study analyzed data from the MyHEART trial, focusing on participants' antihypertensive medication use and categorizing them into groups based on their medication status.
- * Results showed that half of the participants were not on antihypertensives at enrollment, while among those who were, a majority used first-line medications, with variations in usage linked to factors like age, sex, and race.
A simple accurate method for concentration-QTc analysis in preclinical animal models.
J Pharmacol Toxicol Methods
July 2024
Article Synopsis
- In cardiovascular safety studies, researchers focus on the QTc interval to predict changes that may occur in clinical settings, but nonclinical PK data limitations pose a challenge.
- The study involved non-human primates and canines to analyze the relationship between average drug plasma concentration and QTc changes, using statistical methods to establish this correlation.
- Results showed significant QTc changes in both species at specific concentrations of moxifloxacin, indicating that this method of averaging data can effectively model concentration-QTc relationships despite the lack of simultaneous data.
Background: A particular Theory of Care-Seeking Behavior was developed to explain care-seeking behavior with psychosocial concepts, external conditions, and clinical and demographic factors. Having a careful review of studies based on this theory could guide future research on care-seeking behaviors.
Objectives: With a scoping review: describe characteristics of studies guided by a Theory of Care-Seeking Behavior, summarize support for the relationships of proposed, explanatory variables with care-seeking behaviors, and examine support for propositions in the theory.
Background: Women veterans have a high prevalence of traditional and nontraditional risks for cardiovascular disease (CVD) including obesity and posttraumatic stress disorder. Experts from the U.S.
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