Hypoxia-Inducible Factor inhibition affects luteal function with no effect on fertility in mice.

Hypoxia-inducible factors (HIFs) are transcription factors responsible for sensing low oxygen levels and, in response, inducing the transcription of numerous genes. One of the main processes stimulated by HIFs is the formation of new vessels to increase oxygen supply to the tissue. Formation of the corpus luteum strongly depends on the vasculature and an active angiogenesis occurs during luteinization.

Parents' Literacy Beliefs, Home Literacy Activities, and Children's Early Literacy Skills: Stability and Progress Approaching First Grade.

This study explores the stability and progress of parents' literacy beliefs and home literacy activities and their relationships with their children's early literacy skills in their last year of preschool. Participants were 50 preschool children ( = 61.44 months) and their parents.

Elucidating metformin action on the ovary and fertility in healthy mice.

In Brief: The hypoglycemic drug metformin has shown reproductive effects in women, although its mechanism of action is not fully understood. In this study, we demonstrate the direct effects of metformin on the ovary of healthy mice, with no alterations in fertility.

Abstract: Metformin is a hypoglycemic drug widely used in type-2 diabetes (T2D) patients.

Beneficial effects of metformin on mice female fertility after a high-fat diet intake.

Female fertility is highly dependent on energy balance. High fat diet (HFD) intake entails a risk of infertility and ovulatory disorders. Considering the increase in the prevalence of overweight and obesity over the last decades, it is crucial to understand the mechanisms involved in overweight-associated infertility.

Resveratrol alleviates doxorubicin-induced damage in mice ovary.

While oocytes and embryos cryopreservation can favor some patients with cancer-induced infertility to achieve pregnancy, the development of effective therapeutic strategies to preserve ovarian function during chemotherapy would be a significant advantage. The aim of the present study is to analyze whether Resveratrol treatment (Res) can preserve ovarian function from doxorubicin (Doxo)-induced gonadotoxicity using a mice model of premature ovarian failure. Res (7 and 15 mg/kg) increased the percentage of primary and antral follicles whilst decreasing the percentage of atretic follicles compared to Doxo alone.