[Risk of Stroke After Exacerbation of Ischemic Heart Disease: Data of 3‑Years Follow-up].

Purpose: to analyze possible associations of clinical and genetic factors with development of ischemic stroke after exacerbation of ischemic heart disease (IHD).

Materials And Methods: The Russian multicenter study aimed at assessment of risk of unfavorable outcomes after exacerbation of IHD "Exacerbation of IHD: logical probabilistic ways to course prognostication for optimization of treatment" (meaning of Cyrillic acronym - oracle) was conducted in 16 centers of 7 cities in Russia. We included into the study 1 208 patients with unstable angina and ST-elevation or non-ST-elevation myocardial infarction (MI).

[Genetic Features of Factors of Inflammation and Fibrosis Possible Common Pathway of Formation of Predisposition to Atrial Fibrillation and Chronic Obstructive Pulmonary Disease].

Atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) have common pathogenetic mechanisms. It is obvious that hereditary predisposition also increases risk of both diseases. In this context consideration of genetic risk factors will enable in perspective distinguishing a group at highest risk among patients with COPD and become a basis for elaboration of novel approaches to treatment.

[Biomarkers in Heart Failure: Apelin Level Is Not Associated With Presence and Severity of the Disease].

We tested possibility of the use of apelin-12 as a biomarker of chronic heart failure (CHF). The study comprised 108 patients with I-IV functional class CHF of various etiology (ischemic heart disease, dilation cardiomyopathy) and 40 healthy volunteers. Blood samples were taken at hospital admission before prescription of pharmacological therapy.

[Laboratory monitoring of the efficacy and safety of anticoagulants].

Currently, the pharmaceutical market there are a large number of anticoagulants, each of which has a number of features. An important factor influencing the choice of drug, is whether or not the methodology of fixing its efficacy and safety. The aim of this review is to describe current approaches to the control of the efficacy and safety of anticoagulants.

[Degenerative aortic stenosis: prediction of poor prognosis by 2D left ventricular longitudinal strain in non-operated patients].

Aim: To investigate relationship between global longitudinal peak strain (GLPS) of the left ventricle (LV) and clinical routine echocardiographic (ECHO) and electrocardiographic (ECG) parameters in patients with non-operated aortic stenosis (AS) of all degrees. Also we evaluated the prognostic value of GLPS in patients with AS.

Methods: Patients with AS (n = 80) and control patients (n = 49) matched by age, sex and main cardio-vascular diseases were examined.