Durability of Response With Selpercatinib in Patients With -Activated Thyroid Cancer: Long-Term Safety and Efficacy From LIBRETTO-001.

JCO LIBRETTO-001 is a registrational phase I/II, single-arm, open-label study of selpercatinib in patients with (REarranged during Transfection)-activated cancers (ClinicalTrials.gov identifier: NCT03157128). We present long-term safety and efficacy from LIBRETTO-001 in patients with -mutant medullary thyroid cancer (MTC; n = 324) and fusion-positive thyroid cancer encompassing different histological subtypes (TC; n = 66).

Carbon savings from sugarcane straw-derived bioenergy: Insights from a life cycle perspective including soil carbon changes.

Sugarcane straw removal for bioenergy production will increase substantially in the next years, but this may deplete soil organic carbon (SOC) and exacerbate greenhouse gas (GHG) emissions. These aspects are not consistently approached in bioenergy life cycle assessment (LCA). Using SOC modeling and LCA approach, this study addressed the life cycle GHG balance from sugarcane agroindustry in different scenarios of straw removal, considering the potential SOC changes associated with straw management in sugarcane-cultivated soils in Brazil.

Quantifying the qualitative: exploring epistemic network analysis as a method to study work system interactions.

Studying interactions faces methodological challenges and existing methods, such as configural diagramming, have limitations. This work demonstrates Epistemic Network Analysis (ENA) as an analytical method to construct configural diagrams. We demonstrated ENA as an analytical tool by applying this method to study dementia caregiver work systems.

Greenhouse gas emissions and C costs of N release associated with cover crop decomposition are plant specific and depend on soil moisture: A microcosm study.

Cover cropping is used to improve soil quality and increase N inputs in agricultural systems, but it also may enhance greenhouse gases (GHG) emissions. Here, a 47-d incubation study was conducted to track the decomposition process and evaluate GHG emissions and its drivers and to calculate the C costs of residue-derived N released following the addition of residues from cover crops (pigeon pea, cowpea, lablab bean, vetch, and black oat) and maize under two water-filled pore space (WFPS) levels (40 and 70%). For both WFPS levels, the increase in cumulative CO fluxes in plots that received residues is mainly related with the increment of potentially mineralizable C.