Assessing the Experiences of Sexual and Gender Minority Applicants to Orthopaedic Surgery Residency.

Introduction: The rate of sexual and gender minority (SGM) orthopaedic surgeons is far less than in other specialties, and the field has, in part, had significant difficulty attracting SGM applicants. To provide a more welcoming environment, identifying where applicants experience discrimination along medical training must be of paramount concern. Our objective was to understand the challenges faced by SGM medical students applying into orthopaedic surgery.

Mycobiome analyses of critically ill COVID-19 patients.

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and colonization. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality.

Idiopathic Bacterial Peroneal Tenosynovitis: A Case Report and Literature Review.

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Gene Signatures and Oncology Treatment Implications.

Gene expression signatures (GES) are a powerful tool in oncology used for classification, prognostication, and therapeutic response prediction of malignancies. In this article, we review the disease site guidelines by the National Comprehensive Cancer Network that use GES for treatment planning and clinical use. We identified 4 cancer types for which treatment decisions are frequently influenced by GES.

Cell-Cell Fusion in NSCLC Confers a Fitness Benefit Under Drug Selection.

Cell-cell fusion has been implicated in various physiological and pathological processes, including cancer progression. This study investigated the role of cell-cell fusion in non-small cell lung cancer (NSCLC), focusing on its contribution to chemoresistance and tumor evolution. By co-culturing drug-sensitive and drug-resistant NSCLC cell lines, we observed spontaneous cell-cell fusion events, particularly under gefitinib selection.