Synthetic mycolates derivatives to decipher protein mycoloylation, a unique post-translational modification in bacteria.

Protein mycoloylation is a newly characterized post-translational modification (PTM) specifically found in Corynebacteriales, an order of bacteria that includes numerous human pathogens. Their envelope is composed of a unique outer membrane, the so-called mycomembrane made of very-long chain fatty acids, named mycolic acids. Recently, some mycomembrane proteins including PorA have been unambiguously shown to be covalently modified with mycolic acids in the model organism Corynebacterium glutamicum by a mechanism that relies on the mycoloyltransferase MytC.

Widefield optical coherence tomography by electro-optical modulation.

Optical coherence tomography (OCT) is a unique imaging modality capable of axial sectioning with a resolution of only a few microns. Its ability to image with high resolution deep within tissue makes it ideal for material inspection, dentistry, and, in particular, ophthalmology. Widefield retinal imaging has garnered increasing clinical interest for the detection of numerous retinal diseases.

Bioorthogonal Monomycolate of Trehalose Disclosed the -Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in .

Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens. These bacteria possess a distinctive outer membrane, known as the mycomembrane, composed of very long-chain fatty acids called mycolic acids. It has been demonstrated that a few mycomembrane proteins undergo covalent modification with mycolic acids in the model organism through the action of mycoloyltransferase MytC.

Social Anxiety Profiles and Psychopathological Symptom Differences in Spanish Adolescents.

Research on social anxiety (SA) over the years has revealed its associations with different psychopathological symptoms. This study aims to characterize SA profiles in a sample of Spanish adolescents and explore their differences in psychopathological symptoms. Data from 1,288 Spanish students in the 15 to 18 age range (M = 16.