Self-control and limited willpower: Current status of ego depletion theory and research.

Ego depletion theory proposes that self-regulation depends on a limited energy resource (willpower). The simple initial theory has been refined to emphasize conservation rather than resource exhaustion, extended to encompass decision making, planning, and initiative, and linked to physical bodily energy (glucose). Recent challenges offered alternative explanations (which have largely failed) and questioned replicability (which has now been well established).

Controlling CAR-T cell activity and specificity with synthetic SparX adapters.

While conventional chimeric antigen-receptor (CAR)-T therapies have shown remarkable clinical activity in some settings, they can induce severe toxicities and are rarely curative. To address these challenges, we developed a controllable cell therapy where synthetic D-domain-containing proteins (soluble protein antigen-receptor X-linker [SparX]) bind one or more tumor antigens and mark those cells for elimination by genetically modified T cells (antigen-receptor complex [ARC]-T). The chimeric antigen receptor was engineered with a D-domain that specifically binds to the SparX protein via a unique TAG, derived from human alpha-fetoprotein.

Multi-Site Replications in Social Psychology: Reflections, Implications, and Future Directions.

Social psychology findings have fared poorly in multi-site replication attempts. This article considers and evaluates multiple factors that may contribute to such failures, other than the "crisis" assumption that most of the field's published research is so badly flawed that it should be dismissed wholesale. Low engagement by participants may reduce replicability of some findings (while not affecting certain others).

A Review of Multisite Replication Projects in Social Psychology: Is It Viable to Sustain Any Confidence in Social Psychology's Knowledge Base?

Multisite (multilab/many-lab) replications have emerged as a popular way of verifying prior research findings, but their record in social psychology has prompted distrust of the field and a sense of crisis. We review all 36 multisite social-psychology replications (plus three articles reporting multiple ministudies). We start by assuming that both the original and the multisite replications were conducted in honest and diligent fashion, despite often yielding different conclusions.