Publications by authors named "D A Tanguay"

Consideration of sex and gender in research and clinical practice is necessary to redress health inequities and reduce knowledge gaps. As all health professionals must maintain and update their skills throughout their career, developing innovative continuing professional education programs that integrate sex and gender issues holds great promise for reducing these gaps. This article proposes new approaches to partnership, team development, pedagogical theory, content development, evaluation and data management that will advance the integration of sex and gender in continuing professional development (CPD).

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Objectives: The purpose of the present paper is to discuss technical features of endoscopic saphenectomy with CO2 insufflation for CABG surgery and to highlight special situations in which to avoid potential pitfalls that may be encountered.

Methods: The initial section describes the approaches used with endoscopic saphenectomy with insufflation of CO2 at the Montreal Heart Institute and the Wausau Heart Institute, which can be used by operators with different levels of experience. The following sections expose numerous intraoperative tricks and maneuvers to facilitate the procedure.

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An effective humoral response requires that a given B lymphocyte population express a repertoire of receptors capable of recognizing a distinct array of antigens, while at the same time disregarding self-antigens. Mature B cells interacting with antigen via their B cell antigen receptors (BCRs) enter G(1) phase of the cell cycle and, depending on the strength of the signal, can commit to S phase entry. Input from co-receptors, which may function to either enhance or inhibit BCR signals, also influence the decision to proliferate.

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Article Synopsis
  • G-proteins are crucial drug targets, with genetic differences in individuals affecting their response to related medications.
  • Research analyzed the genetic variations in 64 GPCR genes among 82 people from diverse ethnic backgrounds, identifying 675 single-nucleotide variations.
  • Key findings revealed a high prevalence of non-synonymous SNPs in GPCR genes, especially in transmembrane domains, suggesting that genetic variability could significantly impact drug development for these receptors.
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