Publications by authors named "D A Tan"
Background: Recurrent gynecological clear cell carcinoma (rGCCC) has a low objective response rate (ORR) to chemotherapy. Previous preclinical and clinical data suggest a potential synergy between immune checkpoint inhibitors and bevacizumab in rGCCC. Dostarlimab, a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1), combined with the anti-angiogenic bevacizumab, presents a novel therapeutic approach.
View Article and Find Full Text PDFBackground: Liver involvement is a common complication of coronavirus disease 2019 (COVID-19), especially in hospitalized patients. However, the underlying mechanisms involved are not fully understood.
Methods: Immunohistochemistry (IHC) staining of SARS-CoV-2 spike (S) and nucleocapsid (N) proteins was conducted on liver tissues from six patients with COVID-19.
Background: Major society guidelines recommend transarterial chemoembolization (TACE) as the standard of care for intermediate-stage hepatocellular carcinoma (HCC) patients. However, predicting treatment response remains challenging.
Aims: As artificial intelligence (AI) may predict therapeutic responses, this systematic review aims to assess the performance and effectiveness of radiomics and AI-based models in predicting TACE outcomes in patients with HCC.
Investigating Causal Associations of Diet Compositions with the Risk of Lung Cancer.
Nutr Cancer
December 2024
Objective: This study aimed to investigate the causal relationship between diet compositions and lung cancer (LC) risk.
Methods: A two-sample Mendelian randomization (MR) analysis was performed to assess the causal relationship between diet and LC risk, including three LC subtypes. Instrumental variables (IVs) for three diet compositions were selected from genome-wide association studies (GWAS).
Article Synopsis
- The transition from pediatric to adult healthcare for adolescents with HIV in China requires careful planning, and the HIV Adolescent Readiness for Transition Scale (HARTS) aims to fill the gap by assessing readiness across crucial areas.
- The scale comprises 15 items that predict successful post-transition health outcomes, such as viral suppression, and it has undergone a comprehensive validation process involving translation, expert review, and reliability testing among adolescents.
- Results show that HARTS has strong reliability and validity in the Chinese context, with an overall Cronbach's alpha value of 0.943, making it a valuable tool for improving healthcare transition strategies for youth living with HIV.