Publications by authors named "D A Starkova"
Article Synopsis
- Clarithromycin (CLR) is a crucial antibiotic for treating Helicobacter pylori infections, but there is a lack of data on resistance patterns in Russia.
- Researchers used whole genome sequencing (WGS) to analyze 44 clinical H. pylori isolates from 2014-2022, finding that 23 were CLR-resistant while 21 were susceptible.
- The study identified specific genetic mutations in the 23S rRNA gene that reliably predict resistance, and it also compared mutations in virulence-related genes between resistant and susceptible strains, highlighting a significant deletion in the HP0820 gene as a key area for future research.
Detection of the babA2 adhesin protein gene in Helicobacter pylori clinical isolates.
Klin Lab Diagn
September 2022
Article Synopsis
- - The study evaluated two PCR primer sets (271 bp and 832 bp) to detect the babA2 gene in 52 H. pylori clinical samples from patients with chronic gastritis, duodenal ulcer, and stomach cancer in St. Petersburg, Russia.
- - The 271 bp primer set identified 90.4% of the strains as babA2-positive, while the 832 bp set detected only 51.9%; however, there were no significant differences in detection rates between the two sets.
- - Analysis showed no significant correlation between the babA2 gene and the presence of duodenal ulcer or gastric cancer, suggesting that neither primer set is effective for evaluating the virulence of H. pyl
The treatment of children with posterior fossa brain tumours (PFBT) impacts their long term functional and imaging outcomes. This study aimed to evaluate academic achievement correlated with long-term sequelae after different PFBT treatment modalities. The study cohort consisted of 110 survivors (median age at diagnosis 10.
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- The study investigates the genetic variations in Bacille Calmette-Guérin (BCG) vaccine strains, specifically focusing on seed lots used in Russia and their descendants linked to BCG-related diseases in children.
- Through whole-genome sequencing, researchers compared seed lots 361, 367, and 368 with nine progeny isolates and identified specific genetic mutations that could influence vaccine efficacy and virulence.
- The findings suggest that while genetic variations exist, they did not compromise the stability or effectiveness of the BCG vaccine, indicating that changes accumulate during the vaccine's time in the human body.
Article Synopsis
- Japan has a high incidence rate of nontuberculous mycobacterial lung disease, primarily caused by Mycobacterium avium subsp. hominissuis (MAH), with environmental sources like bathrooms suspected to be key infection points.
- A study analyzed samples from 180 residences and found a 16.1% detection rate of MAH, varying by region, with higher rates in Kanto and Kinki compared to much lower rates in other regions.
- Genetic analysis indicated that MAH from bathrooms showed significant genetic similarities to isolates from lung disease patients in Japan, reinforcing the idea that bathrooms are important potential sources of MAH infection.