Publications by authors named "D A Spyker"
Introduction: This is the 41 Annual Report of America's Poison Centers® National Poison Data System®. As of 1 January, 2023, all 55 of the nation's poison centers uploaded case data automatically to NPDS.
Methods: We analyzed the case data, tabulating specific indices from the NPDS®.
Introduction: This is the 40 Annual Report of America's Poison Centers National Poison Data System (NPDS). As of 1 January, 2022, all 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 4.
View Article and Find Full Text PDFAbstractintroduction: This is the 39 Annual Report of America's Poison Centers' National Poison Data System (NPDS). As of 1 January, 2021, all 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 4.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how different acetaminophen (APAP) formulations—immediate release (IR), extended release (ER), and modified release (MR)—affect overdose pharmacokinetics and absorption rates.
- Data was collected from 356 subjects, revealing that both ER and MR formulations show slower absorption and decreased overall exposure compared to IR, especially in cases of overdose.
- The findings suggest that the delayed absorption of ER and MR formulations could complicate clinical assessments, such as the Rumack-Matthew nomogram, by potentially underestimating overdose severity in early treatment stages.