Publications by authors named "D A Shakalis"

The paper presents the data on dietary habits, blood lipid composition, and prevalence of coronary heart disease in native and non-native populations from Buryatia. They were obtained by using epidemiological (assessment of amounts of the food ingredients consumed) and biochemical (measurement of blood levels of total cholesterol, triglycerides, and high density lipoprotein cholesterol) methods. Differences were demonstrated in dietary habits between the native and non-native populations from Buryatia.

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A simultaneous epidemiologic survey was carried out in 1985-1986 to assess plasma lipids and lipoproteins in 30-to-59-year-old male rural residents of Buryatia. Comparative characteristics of plasma lipid profiles are presented for the native populations and newcomers to the land. Buryats and other natives were shown to have lower levels of atherogenic lipoproteins (LDLP CS, VLDLP CS) and lipids (CS, TG) and higher levels of antiatherogenic HDLP CS, as compared to the newcomers.

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Changes in the activity of blood monocytic cholesterol esterase in men with major CHD risk factors (dyslipoproteinemia, arterial hypertension, excessive body mass) were described. Standard methods of epidemiological survey and a radionuclide method to determine cholesterol esterase activity applied to a representative sampling (195 persons) have shown that enzymatic activity was growing with age. In examinees with hyperlipoproteinemia of type IIa and IIb the activity of cholesterol esterase was decreased, and in persons with excessive body mass it was increased.

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Cholesterolesterase activity was assayed in monocytes of coronary patients and normal controls matched for age and showing no evidence of coronary disease. Cholesterolesterase level of coronary patients was significantly lower than that of the controls this two-fold difference in activity being particularly significant in patients with stable angina of effort, functional class 3-4, and progressive angina pectoris. Control subjects tended to have higher cholesterolesterase values than would appear normal for their age.

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