Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, multicentre longitudinal study.

Introduction: Heart failure (HF) is a complex clinical syndrome. Accurate risk stratification and early diagnosis of HF are challenging as its signs and symptoms are non-specific. We propose to address this global challenge by developing the STRATIFYHF artificial intelligence-driven decision support system (DSS), which uses novel analytical methods in determining the risk, diagnosis and prognosis of HF.

Examining Patient Safety Events Using the Behaviour Change Wheel: A Cross-Sectional Analysis.

Background: Precursor-level safety events (PSEs) pose greater patient risk than no-harm events but are not as severe as serious safety events. Despite their potential for harm, the underlying determinants associated with PSEs are poorly understood. This study aimed to use a behavior change framework to understand the underlying determinants of PSEs and whether associated action items aligned with the behavior.

The Wade Programme in surgical anatomy: educational approach and 10-year review.

Background: Against a background of significant changes in UK medical education at both undergraduate and postgraduate levels, the Royal College of Surgeons of Edinburgh (RCSEd) established the Wade Programme in Surgical Anatomy in 2012, as a means of supporting the study of surgical anatomy throughout training. This article provides a 10-year review of the Wade Programme and its educational foundation.

Methods: A novel methodology, the 'Wade Educational Approach', was used in the design and development of a portfolio of professional courses at three training levels: Level 1 - RCSEd Affiliate, Level 2 - Early Years (MRCS) and Level 3 - Later Years (FRCS and CPD).

Convergent effects of synthetic glucocorticoid dexamethasone and amyloid beta in human olfactory neurosphere-derived cells.

Stressful life events and glucocorticoid (stress) hormones appear to increase the risk of Alzheimer's disease and hasten its progression, but the reasons for this remain unclear. One potential explanation is that when amyloid β (Aβ) pathology is accumulating in the preclinical disease stage, glucocorticoid receptor signalling during stressful events exacerbates cellular dysfunction caused by Aβ. Alternatively, Aβ may disrupt glucocorticoid receptor signalling.