Evaluation of the Biological Activities of Dinizia excelsa Wood Essential Oil: A Potential Phytotherapeutic Agent.

The study explored the biological activities of essential oil from Dinizia excelsa wood, highlighting its phytotherapeutic potential. Key analyses included chromatographic profiling, ADMET evaluation, and assessments of antioxidant, antimicrobial, antitumor, immunomodulatory, leishmanicidal, trypanocidal, and schistosomicidal activities. Extracted via hydrodistillation (0.

Psychological Resources and New Product Development Team Adaptability: A Moderated Mediation Model.

Despite the importance of adaptability for new product development team performance, empirical research that explores the factors promoting their adaptive capacity is limited. This study draws from psychological resource theories to examine how and under which conditions team psychological capital enhances the adaptivity of new product development teams. Data were collected from 198 student teams who took part in a project management simulation.

Inequalities in Drug Access for Advanced Melanoma: The Prognostic Impact Resulting From the Approval Delay of the Combined Ipilimumab/Nivolumab Treatment in Portugal.

Introduction A combination of ipilimumab/nivolumab has demonstrated a median overall survival (mOS) of 71.9 months in advanced melanoma, establishing it as the standard first-line (1L) therapy. However, the approval of this combination by the Portuguese Regulatory Authority occurred 76 months after its approval by the European Authority, leaving tyrosine kinase inhibitors as the only 1L option available for the BRAF-mutated melanoma population.

Oxidation-responsive, settable bone substitute composites for regenerating critically-sized bone defects.

Critically-sized bone defects that cannot spontaneously heal on their own remain a significant problem in the clinic. Synthetic polymeric implants are promising therapies for improving bone healing as they are highly tunable and avoid the potential complications associated with autologous bone grafts. However, biostable implants such as poly(methyl methacrylate) (PMMA) suffer from numerous shortcomings including negligible biodegradability and limited osseointegration with bone.

Population-Specific Anatomical Variations in Premolar Root Canal Systems: A Cross-Sectional Cone-Beam Computed Tomography Study of Jamaican and Portuguese Subpopulations.

The morphology of roots and root canals has a significant influence on the outcome of endodontic treatment. This study aimed to compare premolar root and root canal configurations between Central American and European subpopulations using cone-beam computed tomography (CBCT). This cross-sectional retrospective study analyzed CBCT scans of 2919 premolars from 561 patients: 197 from Jamaica (Central America) and 364 from Portugal (Europe).