Publications by authors named "D A Rutland"
Article Synopsis
- Alterations in the activity of enzymes involved in phenylalanine-tyrosine metabolism lead to incomplete breakdown of metabolites, causing increased levels of homogentisic acid (HGA), particularly in the context of alkaptonuria (AKU).
- The study explored the presence of HGA and other metabolites in biofluids and tissues of AKU mice, both treated and untreated with nitisinone, revealing that HGA levels are significantly reduced in bile and that biliary excretion contributes to metabolite distribution.
- A notable finding was that AKU mice excrete approximately 3.8 times more HGA in urine compared to human patients, which may explain the lesser extent of tissue damage (ochronosis
A prototype thermoluminescent dosimetry system for personnel monitoring.
Int J Appl Radiat Isot
July 1966