Publications by authors named "D A Rossignol"
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic review and meta-analysis discovered 204 relevant articles which evaluated biomarkers of mitochondrial dysfunction in ASD individuals. Significant elevations (all p < 0.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) affects up to 1 in 36 children in the United States. It is a heterogeneous neurodevelopmental disorder with life-long consequences. Patients with ASD and folate pathway abnormalities have demonstrated improved symptoms after treatment with leucovorin (folinic acid), a reduced form of folate.
View Article and Find Full Text PDFArticle Synopsis
- There is a high prevalence of epilepsy among individuals with autism spectrum disorder (ASD), but limited information exists on how age and seizure characteristics affect treatment effectiveness.
- An online survey involving 570 individuals with ASD and seizures revealed that seizure severity decreases with age, particularly for generalized tonic-clonic seizures, and that severity is worse in those with genetic disorders or neurodevelopmental regression.
- Certain treatments, like carbamazepine and oxcarbazepine, were more effective when seizures began in later childhood, while surgery and dietary approaches showed better results for early-onset seizures, suggesting a need for personalized treatment strategies in epilepsy care for those with ASD.
Children with autism spectrum disorder may exhibit nutritional deficiencies due to reduced intake, genetic variants, autoantibodies interfering with vitamin transport, and the accumulation of toxic compounds that consume vitamins. Importantly, vitamins and metal ions are essential for several metabolic pathways and for neurotransmitter functioning. The therapeutic benefits of supplementing vitamins, minerals (Zinc, Magnesium, Molybdenum, and Selenium), and other cofactors (coenzyme Q10, alpha-lipoic acid, and tetrahydrobiopterin) are mediated through their cofactor as well as non-cofactor functions.
View Article and Find Full Text PDFCOVID-19 causes not only severe respiratory symptoms, but also long-term sequelae, even if the acute-phase symptoms are minor. Neurological and neuropsychiatric symptoms are emerging as major long-term sequalae. In patients with pre-existing behavioral symptoms, such as individuals with autism spectrum disorders (ASD), the emergence of neuropsychiatric symptoms due to long COVID can be difficult to diagnose and manage.
View Article and Find Full Text PDF