Structure and Corrosion Resistance of Fe40Al5Cr0.2TiB Alloy After Casting and After Homogenization Annealing.

This article shows the results of research conducted on the corrosion resistance of the FeAl (Fe40Al5Cr0.2TiB) alloy in two variants: the alloy after casting and after homogenization annealing (1000 °C, 93 h). Analysis of the microstructure of these alloys was conducted on the light microscope, and the phase composition was determined by X-ray diffraction.

Structural and functional interactions between the Ca-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1).

Ryanodine receptor type 1 (RyR1) releases Ca ions from the sarcoplasmic reticulum of skeletal muscle cells to initiate muscle contraction. Multiple endogenous and exogenous effectors regulate RyR1, such as ATP, Ca, caffeine (Caf), and ryanodine. Cryo-EM identified binding sites for the three coactivators Ca, ATP, and Caf.

Evaluation of Structure and Corrosion Behavior of FeAl Alloy after Crystallization, Hot Extrusion and Hot Rolling.

The paper presents the results of tests on the corrosion resistance of Fe40Al5Cr0.2TiB alloy after casting, plastic working using extrusion and rolling methods. Examination of the microstructure of the Fe40Al5Cr0.

Single-channel properties of skeletal muscle ryanodine receptor pore ΔFF in two brothers with a lethal form of fetal akinesia.

Ryanodine receptor ion channels (RyR1s) release Ca ions from the sarcoplasmic reticulum to regulate skeletal muscle contraction. By whole-exome sequencing, we identified the heterozygous RYR1 variant c.14767_14772del resulting in the in-frame deletion p.

A central core disease mutation in the Ca-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation.

Cryoelectron microscopy and mutational analyses have shown that type 1 ryanodine receptor (RyR1) amino acid residues RyR1-E3893, -E3967, and -T5001 are critical for Ca-mediated activation of skeletal muscle Ca release channel. De novo missense mutation RyR1-Q3970K in the secondary binding sphere of Ca was reported in association with central core disease (CCD) in a 2-yr-old boy. Here, we characterized recombinant RyR1-Q3970K mutant by cellular Ca release measurements, single-channel recordings, and computational methods.