Publications by authors named "D A Oliver"
: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. However, it has poor oral bioavailability. We investigated the effect of a novel lipid formulation on its absorption in humans and on its tissue distribution in mice.
View Article and Find Full Text PDFArticle Synopsis
- Abruptly stopping heavy cannabis use can lead to withdrawal symptoms like irritability, anxiety, insomnia, and in some cases, trigger acute psychosis.
- A systematic review and a comprehensive analysis of psychiatric records identified a total of 112 individuals whose first episodes of psychosis were linked to cannabis withdrawal.
- Continued cannabis use after experiencing a psychotic episode significantly increases the risk of relapse compared to individuals who choose to abstain.
Background And Hypothesis: Transition to psychosis rates within ultra-high risk (UHR) services have been declining. It may be possible to 'enrich' UHR cohorts based on the environmental characteristics seen more commonly in first-episode psychosis cohorts. This study aimed to determine whether transition rates varied according to the accumulated exposure to environmental risk factors at the individual (migrant status, asylum seeker/refugee status, indigenous population, cannabis/methamphetamine use), family (family history or parental separation), and neighborhood (population density, social deprivation, and fragmentation) level.
View Article and Find Full Text PDFBackground And Purpose: Neoadjuvant stereotactic radiosurgery (NaSRS) is an emerging treatment option for brain metastases (BrM) planned for resection. The aim of this study was to report on the efficacy and safety of NaSRS in an individual patient data pooled analysis.
Materials And Methods: Patients undergoing single- and multi-fraction NaSRS for BrM at nine institutions in five countries (Australia, Canada, South Korea, Switzerland and USA) were included.