Lymphoprotective effect of perftoran.

Experiments on rats showed that the lymphoprotective effect of Perftoran manifests in stimulation of contractile activity of myocytes in the wall and valve cusps of lymphatic microvessels, which in turn activates the pump and capacitive functions of the lymphatic system and improves central lymph outflow. These changes contribute to an increase in the resorption and transport of cell and tissue metabolites from the interstitial space.

Content of trace elements in the lymph and blood during pyrogenal-induced fever and complete freund's adjuvant-induced low-grade fever.

Experiments on rats showed that complete Freund's adjuvant-induced low-grade fever and pyrogenal-induced fever are accompanied by an increase in the content of Mn, Cu, Zn, and Se in the thoracic duct lymph. Our results indicate that the lymphatic system supplies trace elements to the circulation, which compensates for a deficiency in trace elements and maintains their systemic circulation. The decrease in the content of some trace elements in the blood during fever is probably associated with their excessive consumption (e.

[Antipyretic system in humans].

The elevation of body temperature during fever reaction and endogenous antipyretic effect reflects the existing balance between 2 components directed to the maximal positive use of the fever effects and simultaneous prevention of their side effects. The mechanisms involved in the control of balance between factors known as the fever triggers and endogenous antipyretic factors. The possible mechanisms of action of various endogenous antipyretic system components (glucocorticoids, neuropeptides, cytokines etc.

Lymphotropic effect of dimephosphon, mexidol, and ketorolac is realized via activation of the lymphangion and stimulation of lymph formation.

Single parenteral administration of dimephosphon, mexidol, and ketorolac produces a lymphotropic effect. Dimephosphon directly affects the lymph system by increasing the number of functioning lymph capillaries and contractile activity of the walls and valves of small intestinal mesenteric lymphangions in rats, which leads to stimulation of lymph circulation. Mexidol and ketorolac increased only lymph flow rate in the thoracic lymph duct, which attested to their indirect effect of the lymph system (presumably associated with stimulation of lymph formation).

Lymphotropic effect of mexidol in reactive fever.

Single injection of mexidol (drug with antioxidant and membranotropic effects) to animals with reactive fever produces a multicomponent effect on the lymph circulation. The drug increased the number of functioning lymph capillaries and contractile activity of wall and valvular leaflets in rat small intestinal mesenteric lymphangion, accelerated lymph drainage, thus stimulating lymph formation and lymph flow.