Publications by authors named "D A McCann"
Retroviruses can be detected by the innate immune sensor cyclic GMP-AMP synthase (cGAS), which recognizes reverse-transcribed DNA and activates an antiviral response. However, the extent to which HIV-1 shields its genome from cGAS recognition remains unclear. To study this process in mechanistic detail, we reconstituted reverse transcription, genome release, and innate immune sensing of HIV-1 in a cell-free system.
View Article and Find Full Text PDFBackground: Stroke has devastating consequences for survivors. Hypertension is the most important modifiable risk factor, and its management largely takes place in primary care. However, most stroke-based research does not occur in this setting.
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- Workplace violence in healthcare, particularly in regional and remote emergency departments in Australia, is increasing in frequency and severity, with limited research available on this issue.
- The study analyzed hospital data from 2018 to identify characteristics of violent incidents, revealing that most incidents occurred early in treatment, involved urgent triage, and often resulted in injuries, predominantly caused by young to middle-aged male patients suffering from mental health or substance use issues.
- Understanding these characteristics can guide targeted interventions to enhance staff safety, improve patient care, and optimize resource management in healthcare settings.
Retroviruses can be detected by the innate immune sensor cyclic GMP-AMP synthase (cGAS), which recognizes reverse-transcribed DNA and activates an antiviral response. However, the extent to which HIV-1 shields its genome from cGAS recognition remains unclear. To study this process in mechanistic detail, we reconstituted reverse transcription, genome release, and innate immune sensing of HIV-1 in a cell-free system.
View Article and Find Full Text PDFBackground: Cocaine use disorder (CUD) is a major public health problem for which there is no approved pharmacotherapy. The primary purpose of this study was to evaluate the ability of lorcaserin, a 5-hydroxytryptamine (5-HT) receptor agonist, to facilitate abstinence in individuals seeking treatment for CUD.
Methods: This was a 12-site, randomized, parallel arm study with a 13-week Treatment Phase that included a 1-week, single-blind run-in period when all participants received twice daily 15mg acetazolamide capsules (a medication adherence marker), followed by randomization to either twice daily 10mg lorcaserin or placebo capsules for the remaining 12 weeks.