Vitamin K Antagonist Reversal for Urgent Surgery Using 4-Factor Prothrombin Complex Concentrates: A Randomized Clinical Trial.

Importance: Millions of people take vitamin K antagonists (VKAs). Some people who need urgent surgical procedures require rapid VKA reversal to prevent excessive intraoperative bleeding.

Objective: To evaluate the hemostatic noninferiority of an investigational 4-factor prothrombin complex concentrate (4F-PCC) to a control 4F-PCC for rapid VKA reversal before urgent surgery.

Highly Permeable Ultrafiltration Membranes Based on Polyphenylene Sulfone with Cardo Fragments.

For the first time, copolymers of polyphenylene sulfone (PPSU) with cardo fragments of phenolphthalein (PP) were synthesized to develop highly permeable flat-sheet ultrafiltration membranes. By introducing cardo fragments into the polymer chain, we achieved a mechanical strength 1.3 times higher than the strength of commercial PPSU.

Effect of Molecular Weight and Chemical Structure of Terminal Groups on the Properties of Porous Hollow Fiber Polysulfone Membranes.

For the first time, polysulfones (PSFs) were synthesized with chlorine and hydroxyl terminal groups and studied for the task of producing porous hollow fiber membranes. The synthesis was carried out in dimethylacetamide (DMAc) at various excesses of 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A) and 4,4'-dichlorodiphenylsulfone, as well as at an equimolar ratio of monomers in various aprotic solvents. The synthesized polymers were studied by nuclear magnetic resonance (NMR), differential scanning calorimetry, gel permeation chromatography (GPC), and the coagulation values of 2 wt.

Reclaiming of Amine CO Solvent Using Extraction of Heat Stable Salts in Liquid-Liquid Membrane Contactor.

Amine CO solvents undergo oxidative degradation with the formation of heat stable salts (HSS). These HSS reduce the sorption capacity of amines and lead to intense corrosion of the equipment. In our work, we propose a membrane-supported liquid-liquid extraction of the HSS from alkanolamines.

Spinning of Polysulfone Hollow Fiber Membranes Using Constant Dope Solution Composition: Viscosity Control via Temperature.

The dope solution viscosity is an important parameter that largely determines the properties of hollow fiber membranes. In the literature available today, the change in viscosity is carried out only by changing the quantitative and/or qualitative dope solution compositions. However, such an important spinning parameter as temperature should significantly affect the dope solution viscosity.