Embryonic Toxicology Evaluation of Ginger- and Clove-mediated Titanium Oxide Nanoparticles-based Dental Varnish with Zebrafish.

Aim: The aim of the study is to evaluate the embryonic toxicology of ginger- and clove-mediated titanium oxide (TiO) nanoparticles (NPs)-based dental varnish with zebrafish ().

Materials And Methods: Dental varnish was formulated using ginger, clove extract, and titanium dioxide NPs followed by the introduction of this test solution at concentrations of 1, 2, 4, 8, and 16 µL along with a control group with medium zebrafish embryos into a 6-well culture plate. After 2 hours of incubation, the embryos of zebrafish were tested and analyzed for hatchability and mortality rate using one-way ANOVA and Tukey's tests using statistical package for the social sciences (SPSS) software.

Repurposing the Bis-Biguanide Alexidine in Combination with Tyrosine Kinase Inhibitors to Eliminate Leukemic Stem/Progenitor Cells in Chronic Myeloid Leukemia.

Background & Aims: In CML, Leukemic Stem Cells (LSCs) that are insensitive to Tyrosine Kinase Inhibitors are responsible for leukemia maintenance and relapses upon TKI treatment arrest. We previously showed that downregulation of the BMI1 polycomb protein that is crucial for stem/progenitor cells self-renewal induced a CCNG2/dependent proliferation arrest leading to elimination of Chronic Myeloid Leukemia (CML) cells. Unfortunately, as of today, pharmacological inhibition of BMI1 has not made its way to the clinic.