Publications by authors named "D A Leibowitz"
Enlargement of the left ventricle (LV) is an important marker of adverse cardiac remodeling and poor prognosis. Previous studies demonstrated increased cardiovascular risk in small subsets of patients with a small LV chamber size; however, the prognostic implications of small chamber size in the general population remains unclear. This study aimed to examine the prognosis of a small LV chamber in a large general cohort.
View Article and Find Full Text PDFIntroduction: Heart failure with improved ejection fraction (HFimpEF) is a recently defined subtype of HF, characterized by an increase in ejection fraction (EF) after a prior diagnosis of reduced EF. There are limited data on the characteristics and outcome of this patient subset. The study aimed to investigate the clinical profile and prognosis of this patient group.
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- The study investigates the dimensionless index (DI) in patients with aortic stenosis (AS), highlighting its ease of measurement and reduced susceptibility to error compared to traditional methods.
- Analyzing data from 9,393 patients, the study finds that a low DI correlates with factors such as older age, heart failure, and worse overall heart function.
- Results indicate that lower DI is linked to significantly higher mortality rates and poor event-free survival, suggesting DI should be routinely included in assessing patients with aortic valve disease.
Article Synopsis
- * In a study of 934 stroke-free participants, 69.1% had aortic arch plaques, with larger plaques correlating with a significantly higher rate of combined cardiovascular events in statin users.
- * Findings suggest that aortic arch plaques may indicate overall cardiovascular risk rather than serving solely as a source of embolic strokes.
The impact of aging on cardiac remodeling in chronic mitral regurgitation.
J Geriatr Cardiol
October 2023
Background: Chronic mitral regurgitation (MR) is a volume overload state that causes dilatation of the left sided cardiac chambers. The presence of significant dilatation is considered an indication for mitral valve intervention, however, aging may affect left ventricular (LV) remodeling independently of valvular disease. The objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic MR.
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