Publications by authors named "D A Kuzmin"

The endoscopic transsphenoidal approach is a common approach used in skull base neurosurgery to reach the sellar region. One of the intraoperative risks of this approach is intraoperative bleeding out of the carotid artery. Gentle drilling can prevent carotid artery injury.

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Background: Surgical treatment of therapy-resistant radiculopathy associated with lumbar herniated discs in patients with extreme obesity is a challenge for neurosurgeons. In addition to technical problems in surgery due to the abundant subcutaneous adipose tissue and perioperative risks, there are significant anesthetic risks when anesthesia is performed with a patient in the prone position. A surgical procedure should preferably be minimally traumatic and quick with minimal risks of complications.

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The most effective method of treating tumors localized in the liver remains resection. However, in the presence of concomitant pathology, the regenerative potential of the liver is significantly reduced. To date, there is insufficient fundamental data on the mechanisms responsible for the disruption of liver regeneration, and there is no effective method for assessing its regenerative potential.

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Introduction: The differential ratio of nonsynonymous to synonymous nucleotide substitutions (dN/dS) is a common measure of the rate of structural evolution in proteincoding genes. In addition, we recently suggested that the proportion of transposable elements in gene promoters that host functional genomic sites serves as a marker of the rate of regulatory evolution of genes. Such functional genomic regions may include transcription factor binding sites and modified histone binding loci.

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Article Synopsis
  • A study combined dendrochronological (tree-ring data) and genomic data to explore how Siberian stone pine adapts genetically to climate change and environmental stressors.
  • Researchers analyzed 84,853 genetic markers (SNPs) and 110 tree traits from 234 trees across six populations to understand the genetic structure and adaptive potential of these trees.
  • The analysis revealed a weak genetic differentiation among populations and identified 30 SNPs linked to tree traits; notably, three SNPs associated with recovery from climatic stress were found across various methods, suggesting their potential adaptive importance.
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