[PHF10, a Subunit of the PBAF Chromatin Remodeling Complex, Changes Its Localization and Interacts with c-FOS during the Initiation of Long-Term Potentiation in Neuronal Culture].

The PBAF chromatin remodeling complex interacts with many transcriptional activators and is recruited to target chromatin regions. PBAF plays an important role in maintaining and modifying the chromatin structure in mammalian cells. A subunit of the PBAF complex, the PHF10 transcription factor, is required for proliferation of neuronal precursors in the early stages of mouse brain development and gene expression in differentiated neurons.

[COMPARATIVE STUDY OF NIGROSTRIATAL SYSTEMS IN WISTAR RATS AND RATS PRONE TO SEIZURES].

In this work we analyzed the levels of functional activity of dopaminergic, GABA-ergic and glutamatergic neurons in the nigrostriatal system of control Wistar rats and Krushinsky-Molodkina (KM) rats prone to audiogenic seizures. In KM rats we have revealed disturbed activity of GABA- and dopaminergic neurons in substania nigra whereas the level of glutamatergic neurotransmission remained unchanged. We have also observed no significant differences in GAD65/67 and phospho-tyrosine hydroxylase contents in the striatum of KM and control Wistar rats.