[About the human health safety estimation of ractopamine intake together with the food].

The analysis of scientific data including American and European scientific communities concerning use of ractopamine as a growth factor in food animal production and the argumentation of the maximum permitted levels of ractopamine and levels of ractopamine in meat and byproducts (offal) is carried out. The position of the Russian side stated at the Codex Alimentarius commission 35th session that acceptable ractopamine daily intake is insufficiently validated and cannot be used for the determination of maximum permitted levels of ractopamine in meat and byproducts (offal) is confirmed. It is represented that residual ractopamine intake together with food on the levels which are recommended by the Codex Alimentarius commission and by taking into account the levels of animal products consumption in Russian Federation will lead to unacceptable human health risk level that will promote increasing heart diseases and life expectancy reduction.

[Hygienic evaluation of immune and endocrine systems and modifications of their relationship in reproductive-age women working under exposure to chemical factors in activated carbon emissions].

The article presents results of the evaluation the changes in the relationships between immune and endocrine systems in reproductive-age women, working under exposure to chemical factors from activated carbon production. A significant increase of some chemical elements and compounds was found in blood that was associated with changes in the endocrine and immune status, as well as the presence of features in correlation parameters of these systems in reproductive-age women, working under exposure to chemical factors.

[Mathematic concept model of accumulation of functional disorders associated with environmental factors].

The mathematic concept model presented describes accumulation of functional disorders associated with environmental factors, plays predictive role and is designed for assessments of possible effects caused by heterogenous factors with variable exposures. Considering exposure changes with self-restoration process opens prospects of using the model to evaluate, analyse and manage occupational risks. To develop current theoretic approaches, the authors suggested a model considering age-related body peculiarities, systemic interactions of organs, including neuro-humoral regulation, accumulation of functional disorders due to external factors, rehabilitation of functions during treatment.

[Qualitative assessment of a noncarcinogenic risk to human health].

The existing methodic approaches to analyzing a noncarcinogenic risk fail to fully solve the tasks set within the basic lines of the activities of the Russian Agency for Consumer Surveillance since there are limited capacities of the quantitative assessment of a noncarcinogenic risk to human health. An algorithm is proposed for basing the indicators assessing a noncarcinogenic risk to human health, which assumes to determine exposure or an exposure marker for a cohort to be examined, to define a response to human health exposure, to construct mathematical "exposure (an exposure marker)-response" models, to determine the ineffective levels exposure for each type of a response, to make the piecewise-linear approximation of a model, and to calculate a slope factor for each linearized interval of an exposure-response model. Application of the proposed methodic approaches makes it possible, provided that the estimation of the cost of risk units, to assess the economic loss risk associated with the pollution of environmental objects, including a preventable risk, and to calculate the indicators of the effectiveness and efficiency of the activities of the bodies and organizations of the Russian Agency for Consumer Surveillance in reducing the risk to the population's health.

[Effect of monohydric aliphatic alcohols on children's health].

To form the evidence base of the "environmental determination" of disease is a topical line in human ecology and environmental hygiene. The widespread use of monohydric aliphatic alcohols in industry has determined the necessity of making an in-depth study of their toxic effects on man, by taking into account their actual concentrations forming in the blood. The results of the studies have led to the conclusion that the real risk of toxic exposure of an organism to monohydric alcohols forms when the blood concentrations of butyl alcohols, propyl alcohols, and methyl alcohol are over 0.