[Registry-based comparison of multiple sclerosis epidemiology trend data in 1999 and 2019: the case of Yaroslavl].

Objective: To compare the epidemiological indicators of multiple sclerosis (MS) in Yaroslavl when comparing the 1999 and 2019 registers to study the pathomorphism of the disease in this territory.

Material And Methods: During the work, the data of the 1999 and 2019 registers were used, including the age of the debut, the date of diagnosis, the form of the disease, clinical characteristics, the treatment received and its duration. In 1999, 257 patients living in the city of Yaroslavl (155 women and 102 men) were included in the MS registry with a reliable diagnosis of MS according to Poser's criteria with confirmation according to neuroimaging data.

[Clinical and epidemiological peculiarities of multiple sclerosis in patients with different level of essential and toxic chemicals in blood serum].

Multiple sclerosis as it seen presently is a disease determined by the interaction of genetic and environmental factors. Risk factors are some chronic infections and living in ecological hazard areas. In this aspect, the authors review a role of metals which remains unclear so far.

[The influence of environmental factors on the incidence and prevalence of multiple sclerosis].

257 patients with multiple sclerosis (MS) participated in the study in Yaroslavl region. The main epidemiological indices (incidence and prevalence of MS) for the last 25 years were determined. The evaluation of environment pollution has been realized in different districts of the city according to the level of snow covering pollution.