Drug Delivery in PROSE Device as Alternative to Frequent Drop Administration in Severe Ocular Surface Disease.

The design of the prosthetic replacement of the ocular surface ecosystem (PROSE) device allows it to serve as a novel drug delivery system. In this article, we describe the off-label administration of amphotericin B and cenegermin by instillation in the PROSE device reservoir for the treatment of Candida keratitis in the setting of a persistent epithelial defect.

United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus.

Background: There is significant heterogeneity in cardiovascular disease (CVD) risk among patients with diabetes mellitus (DM).

Objectives: The purpose of this study was to develop risk scores for total CVD and its components from a contemporary pooled, observational cohort of U.S.

Development of a physical performance summary score in middle age: Findings from the CARDIA Function study.

Few physical performance batteries exist that appropriately evaluate physical limitations in middle-aged adults. We aimed to develop a physical performance summary score that is appropriate for use in epidemiology studies of middle-aged adults using data from the Coronary Artery Risk Development in Young Adults (CARDIA) Function study, which assessed self-reported function (PROMIS-SF20a) and physical performance measures (gait speed, balance, lower-body strength, grip strength, and cardiovascular endurance). The CARDIA Physical Performance (CAPP) score was developed using sex-specific quartiles, assigning points based on these quartiles (0 for not attempted, 1-4 for each quartile), and summing points across all performance measures (0-20, higher scores reflect greater performance).