Publications by authors named "D A Higuchi"
Vulvar adenocarcinoma of the intestinal type (VAIt) is a rare subtype of primary vulvar carcinoma, with ∼30 cases documented in the English literature. This study presents 2 new cases of HPV-independent VAIt with lymph node metastasis and discusses their clinical presentation, histopathologic features, and whole exome sequencing (WES) analysis. Both cases exhibited histologic features consistent with VAIt, including tubular, papillary, and mucinous carcinoma components.
View Article and Find Full Text PDFThis study aimed to test the hypothesis that knowledge derived from indirect assessments can be used to identify fall risk factors during a period of social distancing. A baseline survey of 1953 community-dwelling older adults was conducted in May 2020, with a follow-up survey performed in May 2023 to assess the situation 3 years later. In total, 339 individuals were followed from baseline to follow-up.
View Article and Find Full Text PDFObjective: The 2023 International Federation of Gynecology and Obstetrics classification with molecular classification shows superior discriminatory ability compared to staging systems lacking molecular data. However, the accuracy of endometrial biopsy data in molecular classification remains uncertain. This study aimed to assess the concordance of molecular classifications between preoperative biopsy and hysterectomy to predict prognosis before surgical staging.
View Article and Find Full Text PDFArticle Synopsis
- Drug-induced kidney injury (DIKI) is a key factor in acute kidney injury (AKI), primarily affecting renal proximal tubular epithelial cells (RPTECs) which play a crucial role in drug processing in the kidneys.* -
- The study utilized three-dimensional cultured human RPTECs (3D-RPTECs) and found that certain drugs, like tenofovir and cisplatin, reduced ATP levels in these cells, indicating potential toxicity.* -
- 3D-RPTECs demonstrated high sensitivity (82.4% to 88.2%) and specificity (100% to 93.3%) in predicting DIKI when compared to traditional two-dimensional cell cultures, suggesting they are a valuable tool
Objective: To compare the outcomes of surgical stabilization of pediatric supracondylar humeral fractures with the use of crossed Kirschner wires versus divergent lateral pinning wires.
Methods: This is a systematic review with meta-analysis carried out by searching the MEDLINE/PubMed, Science Direct and Scielo databases. In these, the search for journals was carried out between January and August 2023, where 695 studies were found.