Zh Vopr Neirokhir Im N N Burdenko
August 2024
The strategy for the synthesis of substituted [(3-nitro-1-1,2,4-triazol-1-yl)--azoxy]furazans 4-7, in which the distal nitrogen of the azoxy group is bonded to the nitrogen atom of the azole ring, includes, firstly, the reaction of 1-amino-3-nitro-1-1,2,4-triazole with 2,2,2-trifluoro--(4-nitrosofurazan-3-yl)acetamide in the presence of dibromisocyanuric acid followed by removing of the trifluoroacetyl protecting group to afford aminofurazan (4). Transformation of the amino group in the latter made it possible to synthesize the corresponding nitro (5), azo (6), and methylene dinitramine (7) substituted furazans. The compounds synthesized are thermally stable (decomposition onset temperatures 147-228 °C), exhibit acceptable densities (1.
View Article and Find Full Text PDFUnlabelled: Telocytes (Tcs) and pericytes (Pcs) are two types of perivascular interstitial cell known to be widespread in various organs and tissues, including the brain. We postulated that Tcs and Pcs may be involved in glioblastoma (GBM) neovascularization.
Objective: Morphological study of Tc and Pc roles in GBM.