Publications by authors named "D A Goss"
A biomimetic sperm selection device for routine sperm selection.
Reprod Biomed Online
September 2024
Research Question: Can a biomimetic microfluidic sperm sorter isolate motile sperm while minimizing DNA damage in comparison with density gradient centrifugation (DGC)?
Design: This was a two-phase study of 61 men, consisting of a proof-of-concept study with 21 donated semen samples in a university research laboratory, followed by a diagnostic andrology study with 40 consenting patients who presented at a fertility clinic for semen diagnostics. Each sample was split to perform DGC and microfluidic sperm selection (one-step sperm selection with 15 min of incubation) side-by-side. Outcomes evaluated included concentration, progressive motility, and DNA fragmentation index (DFI) of raw semen, and sperm isolated using DGC and the microfluidic device.
Small extracellular vesicles (sEVs) are membranous vesicles released from cellular structures through plasma membrane budding. These vesicles contain cellular components such as proteins, lipids, mRNAs, microRNAs, long-noncoding RNA, circular RNA, and double-stranded DNA, originating from the cells they are shed from. Ranging in size from ≈25 to 300 nm and play critical roles in facilitating cell-to-cell communication by transporting signaling molecules.
View Article and Find Full Text PDFBackground: In-clinic gait retraining has been effective in modifying suspected biomechanical risk factors for running injury, but its feasibility is often limited by multiple clinic visits. This randomized clinical trial investigated the effects of a telehealth-based gait retraining intervention on running biomechanics, pain, and function in previously injured runners.
Methods: Twenty-three participants recovering from lower extremity injuries were randomized to a control or intervention group.
Protein translation is globally downregulated under stress conditions. Many proteins that are synthesized under stress conditions use a cap-independent translation initiation pathway. A subset of cellular mRNAs that encode for these proteins contain stable secondary structures within their 5'UTR, and initiate cap-independent translation using elements called cap-independent translation enhancers or internal ribosome entry sites within their 5'UTRs.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the prevalence of human papillomavirus (HPV) in nasopharyngeal carcinoma (NPC) across different regions, given that HPV's role in cancer types outside the oropharynx isn't well understood.
- - Using data from various databases, researchers analyzed 46 studies involving 6,314 NPC patients, finding a global HPV+NPC prevalence of 0.18, with higher prevalence in North America compared to Asia.
- - The results indicate that HPV, particularly types 16 and 18, contributes significantly to NPC cases in North America, suggesting a need for further understanding of its role in regions where NPC is less common.