Publications by authors named "D A Fullerton"
Article Synopsis
- Human aortic valve interstitial cells (AVICs) from calcific aortic valve disease (CAVD) show increased fibrocalcific activity, and the study aims to uncover factors that promote this process.
- Proteomic analysis revealed elevated levels of cathepsin D in AVICs from diseased valves, leading to increased expression of fibrocalcification markers like Runx2 and collagen deposition when cathepsin D was introduced.
- The study concludes that elevated cathepsin D in diseased AVICs promotes fibrocalcification through the ERK1/2-Sox9 pathway, highlighting its potential role in the progression of CAVD.
Chronic kidney disease (CKD) is linked to greater prevalence and rapid progression of calcific aortic valve disease (CAVD) characterized by valvular leaflet fibrosis and calcification. Fibroblast growth factor 23 (FGF23) level is elevated, and anti-aging protein Klotho is reduced in CKD patients. However, the roles of FGF23 and Klotho in the mechanism of aortic valve fibrosis and calcification remain unclear.
View Article and Find Full Text PDFAims: There is wide variability in the practice of cardiac preservation for heart transplantation. Prior reports suggest that the type of solution may be linked with a reduced incidence of posttransplantation complications.
Methods: Adult (≥18 years old) heart recipients who underwent transplantation between 2015 and 2021 in the United States were examined.
Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity.
Front Cardiovasc Med
November 2023
Introduction: Sepsis is prevalent in the elderly population with increased incidence and mortality. Currently, the mechanism by which aging increases the susceptibility to sepsis and worsens outcome is unclear. We tested the that aging exacerbates cardiac dysfunction in sepsis through a Toll-like receptor 2 (TLR2)-dependent mechanism.
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