Publications by authors named "D A Frassica"
Article Synopsis
- The study aimed to compare cancer control outcomes between patients with high-grade soft tissue sarcomas treated with neoadjuvant chemoradiation (CRT) and those treated with radiation therapy (RT) alone.
- A total of 64 patients were analyzed, revealing that the RT group was older, with more cardiovascular disease compared to the CRT group.
- After adjusting for differences, both groups showed similar rates of local control, disease-free survival, and overall survival; however, CRT patients experienced higher acute dermatitis and surgical complications.
Article Synopsis
- - The study aimed to analyze how the volume of soft tissue sarcomas changes during radiation therapy (RT) and its relevance before surgery, focusing on patients treated from 2013 to 2016.
- - Out of 33 patients, 16 tumors showed significant volume changes during RT, with 11 decreasing and 5 increasing; specific tumor types and treatment methods were linked to these changes.
- - Although volume changes reflected certain tumor characteristics, they did not serve as reliable indicators for surgical resection margins or the likelihood of cancer recurrence after surgery.
Background: Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy.
View Article and Find Full Text PDFObjectives: High-grade soft-tissue sarcoma (STS) has a poor prognosis. The goal of this study was to review treatment outcomes of patients with high-grade STS treated with interdigitated neoadjuvant chemotherapy (CT) and radiation at our institution.
Materials And Methods: Patients with high-grade STS (1997 to 2010) were planned for treatment with 3 cycles of neoadjuvant CT, interdigitated preoperative radiation therapy (44 Gy administered in split courses with a potential 16 Gy postoperative boost), and 3 cycles of postoperative CT.