A gamma-ray imaging method for multiple radionuclides and low-activity radioactive sources.

Gamma-ray coded-aperture imaging technology has important applications in the fields of nuclear security, isolated source detection, and the decommissioning of nuclear facilities. However, artifacts can reduce the quality of reconstructed images and affect the identification of the intensity and location of radioactive sources. In this paper, a gamma-ray coded-aperture imaging method based on primitive and reversed coded functions (PRCF) was proposed to reduce imaging artifacts.

Superior selectivity for efficiently reductive degradation of hydrophobic organic pollutants in strongly competitive systems.

Highly toxic halo-/nitro-substituted organics, often in low concentrations and with high hydrophobicity, make it difficult to obtain electrons for reduction when strongly electron-competing substances (e.g., O, H/HO, NO) coexist.

sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden.

Objectives: The aims of this study were to investigate whether CSF sTREM2 may be a potential marker of disease monitoring for amyotrophic lateral sclerosis (ALS).

Methods: We investigated whether CSF sTREM2 levels are altered in ALS patients and are correlated with upper motor neuron (UMN) burden and disease progression.

Results: CSF sTREM2 was greater in the ALS patients than in the controls ( = 0.

Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods.

Background: We have previously developed a candidate therapeutic HPV DNA vaccine (pBI-11) encoding mycobacteria heat shock protein 70 linked to HPV16/18 E6/E7 proteins for the control of advanced HPV-associated oropharyngeal cancer (NCT05799144). While naked DNA vaccines are readily produced, stable, and well tolerated, their potency is limited by the delivery efficiency. Here we compared three different IM delivery strategies, including intramuscular (IM) injection, either with a needle alone or with electroporation at the injection site, and a needle-free injection system (NFIS), for their ability to elicit gene expression and to improve the potency of pBI-11 DNA vaccine.

Quercetin Promote the Chemosensitivity in Organoids Derived from Patients with Breast Cancer.

Aim: The study aimed to culture organoids from tissues of patients with breast cancer (BC) and use the organoids to measure the sensitivity to quercetin and its combination with chemotherapeutic agents.

Methods: Four patient-derived organoids (PDOs) of BC were cultured. The proliferative activity and morphology of PDOs were evaluated on different generations and after resuscitation.