Publications by authors named "D A Esquenazi"
Leprosy reactions are an acute and systemic manifestation, which occurs suddenly, can be severe and lead leprosy patients to disability. Reactional episodes are observed among half of the multibacillary patients, mainly in borderline lepromatous and lepromatous forms. They may begin at any time during multidrug therapy, and even before the treatment.
View Article and Find Full Text PDFLeprosy is an infectious disease that remains endemic in approximately 100 developing countries, where about 200,000 new cases are diagnosed each year. Moreover, multibacillary leprosy, the most contagious form of the disease, has been detected at continuously higher rates among Brazilian elderly people. Due to the so-called immunosenescence, characterized by several alterations in the quality of the immune response during aging, this group is more susceptible to infectious diseases.
View Article and Find Full Text PDFBackground: Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates in elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M. leprae.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 reaction (T2R) is an acute inflammatory episode typically found in lepromatous leprosy patients, linked to changes in T lymphocytes and their immune responses.
- The study analyzed T cell subpopulations from leprosy patients, focusing on cytokine production and transcription factor expression, using flow cytometry and real-time PCR techniques.
- Findings showed increased CD8/TNF effector memory T cells in T2R patients, reduced IFN-γ-producing cells, and correlations between immune cell types and the bacteriological index, suggesting that CD8/TNF T cells significantly impact the immune response in ENL patients.
Background: Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infection. In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities.
Principal Findings: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients.