Implementing a smoke-free generation policy for Canada: estimates of the long-term impacts.

Introduction: The aim of this study was to assess the potential impacts of the introduction of a smoke-free generation (SFG) policy in Canada with a perpetual ban on cigarette sales to anyone born after 2009 instigated on 1 January 2025.

Methods: An existing Canadian model relating to smoking cessation was adapted and augmented to assess the impact of an SFG policy on quality-adjusted life years (QALYs), life expectancy, health care costs, smoking-related taxes, and Canadian tobacco industry gross domestic product (GDP). The cumulative impact of the policy for the entire Canadian population was assessed for time horizons up to 90 years with an annual discount rate of 1.

How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England.

Objective: The proportion of people having home dialysis for kidney disease varies considerably by treating centre, socioeconomic deprivation levels in the area and to some extent ethnicity. This study aimed to gain in-depth insights into cultural and organisational factors contributing to this variation in uptake.

Design: This is the first ethnographic study of kidney centre culture to focus on home dialysis uptake.

A machine learning approach for identifying anatomical biomarkers of early mild cognitive impairment.

Background: Alzheimer's Disease (AD) poses a major challenge as a neurodegenerative disorder, and early detection is critical for effective intervention. Magnetic resonance imaging (MRI) is a critical tool in AD research due to its availability and cost-effectiveness in clinical settings.

Objective: This study aims to conduct a comprehensive analysis of machine learning (ML) methods for MRI-based biomarker selection and classification to investigate early cognitive decline in AD.

A review of non-microbial biological control strategies against the Asian longhorned beetle (Coleoptera: Cerambycidae).

The Asian longhorned beetle (ALB), Anoplophora glabripennis (Motschulsky), is a polyphagous woodboring beetle that infests and damages hardwood host trees in Asia, Europe, and North America. Native to China and the Korean peninsula, ALB is invasive in both North America and Europe. Due to the large environmental and economic impacts associated with ALB, much effort has been placed on its management and eradication from invaded areas.

Considerations when applying equity weights within economic evaluation when making drug reimbursement decisions.

When decision-makers use economic evaluation to facilitate making decisions about reimbursing whether to reimburse pharmaceuticals within a publicly funded health care system, they may consider whether to prioritise specific patient populations or diseases: e.g., cancer or rare disease.