Publications by authors named "D A Carroll"
A Close Look at Dissolved Silica Dynamics in Disko Bay, West Greenland.
Global Biogeochem Cycles
January 2025
Article Synopsis
- The discharge of calved ice and subglacial runoff in Disko Bay, home to Sermeq Kujalleq glacier, is expected to influence marine biogeochemistry, particularly affecting the marine silica cycle due to elevated dissolved silica (dSi) from glaciers.
- The study analyzes silica dynamics in various regions around Disko Bay, finding that land-terminating glaciers show conservative dSi patterns, whereas marine-terminating glaciers significantly alter nutrient distribution through subglacial discharge plumes.
- The research quantifies contributions to dSi enrichment, highlighting that a large fraction comes from saline water entrainment, with minor contributions from icebergs and amorphous silica dissolution, ultimately adding a small but significant dSi flux to the environment.
Background: The American Association of Colleges of Pharmacy Curriculum Outcomes and Entrustable Professional Activities (COEPA) recognize the need for social determinants of health (SDH) education for pharmacy learners. However, there is a dearth of published strategies for incorporating comprehensive SDH education in Doctor of Pharmacy curricula. The objectives of this study were to: 1) highlight unpublished exemplars of SDH teaching models and 2) propose strategies for teaching SDH.
View Article and Find Full Text PDFA congenital lumbar hernia is a rare type of hernia that can affect children born with lumbo-costo-vertebral syndrome. This case report is the first to describe a hybrid laparoscopic-assisted approach, which enabled precise intra-operative localization of a pediatric congenital lumbar hernia, and definitive surgical repair was then undertaken through an open approach. Unlike prior studies that have focused solely on either open or laparoscopic techniques, this hybrid approach offers a new strategy to improve surgical accuracy, particularly where imaging and clinical examination are inconclusive.
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- The study focuses on the role of increased intracellular calcium (Ca) during fertilization in sea stars, which is crucial for restarting zygote metabolism and preventing polyspermy.
- Researchers used two bioinformatics strategies to identify transcripts coding for proteins with SH2 domains in the mature egg transcriptome, finding a total of 82 transcripts.
- The novel method discovered 33 of these transcripts that were not identified by the traditional approach, offering new targets for future experiments on egg activation.
One challenge in studies using tissue collected from multiple cohorts is avoiding batch effects when preparing for large-scale multi-omic experiments, such as combined single-cell RNA sequencing and metabolomics. The method in the current study utilizes flash-frozen pancreatic islets from fetal non-human primates collected over a span of two years for input into single-nucleus RNA sequencing and ATAC sequencing assays. The cytosolic fraction generated during nuclear extraction was retained for downstream capillary electrophoresis-mass spectrometry and subsequent metabolite quantification.
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