Publications by authors named "D A Burke"
Dopamine critically regulates neuronal excitability and promotes synaptic plasticity in the striatum, thereby shaping network connectivity and influencing behavior. These functions establish dopamine as a key neuromodulator, whose release properties have been well-studied in rodents but remain understudied in nonhuman primates. This study aims to close this gap by investigating the properties of dopamine release in macaque striatum and comparing/contrasting them to better-characterized mouse striatum, using ex vivo brain slices from male and female animals.
View Article and Find Full Text PDFNoncoding satellite DNA repeats are abundant at the pericentromeric heterochromatin of eukaryotic chromosomes. During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known as chromocenters. Despite the pivotal role of chromocenters in cellular processes like genome encapsulation and gene repression, the associated proteins remain incompletely characterized.
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- Type B aortic dissection with serious complications, like a large entry tear and circumferential dissection, poses a higher risk of progression and rupture without surgery.
- Traditional treatment involves complicated procedures to prevent stroke when placing a stent, but new endovascular graft technology has improved treatment options.
- A case study of a 53-year-old man with a severe type B dissection demonstrates a two-step treatment approach using carotid bypass followed by endovascular repair with a GORE TAG device.
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- * While tyrosine kinase inhibitors (TKIs) have improved survival, resistance and disease progression are common, highlighting the need for new treatment options.
- * Research shows that an anti-EGFR aptamer (EGFRapt) can reduce tumor growth in LUAD cells with specific mutations, offering a promising alternative therapeutic strategy that operates through different mechanisms than current treatments.
Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map.
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