Evaluating the Performance of ChatGPT in the Prescribing Safety Assessment: Implications for Artificial Intelligence-Assisted Prescribing.

Objective With the rapid advancement of artificial intelligence (AI) technologies, models like Chat Generative Pre-Trained Transformer (ChatGPT) are increasingly being evaluated for their potential applications in healthcare. The Prescribing Safety Assessment (PSA) is a standardised test for junior physicians in the UK to evaluate prescribing competence. This study aims to assess ChatGPT's ability to pass the PSA and its performance across different exam sections.

Narrative predicts cardiac synchrony in audiences.

Audio-visual media possesses a remarkable ability to synchronise audiences' neural, behavioural, and physiological responses. This synchronisation is considered to reflect some dimension of collective attention or engagement with the stimulus. But what is it about these stimuli that drives such strong engagement? There are several properties of media stimuli which may lead to synchronous audience response: from low-level audio-visual features, to the story itself.

GMP implementation of a hybrid continuous manufacturing process for a recombinant non-mAb protein-A case study.

Advances in manufacturing technology coupled with the increased potency of new biotherapeutic modalities have created an external environment where continuous manufacturing (CM) can address a growing need. Amgen has successfully implemented a hybrid CM process for a commercial lifecycle program. In this process, the bioreactor, harvest, capture column, and viral inactivation/depth filtration unit operations were integrated together in an automated, continuous module, while the remaining downstream unit operations took place in stand-alone batch mode.

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

Phospholipase C-gamma 2 (PLCγ2) is highly expressed in hematopoietic and immune cells, where it is a key signalling node enabling diverse cellular functions. Within the periphery, gain-of-function (GOF) PLCγ2 variants, such as the strongly hypermorphic S707Y, cause severe immune dysregulation. The milder hypermorphic mutation PLCγ2 P522R increases longevity and confers protection in central nervous system (CNS) neurodegenerative disorders, implicating PLCγ2 as a novel therapeutic target for treating these CNS indications.

BVI-VFI: A Video Quality Database for Video Frame Interpolation.

Video frame interpolation (VFI) is a fundamental research topic in video processing, which is currently attracting increased attention across the research community. While the development of more advanced VFI algorithms has been extensively researched, there remains little understanding of how humans perceive the quality of interpolated content and how well existing objective quality assessment methods perform when measuring the perceived quality. In order to narrow this research gap, we have developed a new video quality database named BVI-VFI, which contains 540 distorted sequences generated by applying five commonly used VFI algorithms to 36 diverse source videos with various spatial resolutions and frame rates.