Publications by authors named "D A Bruns"
The age of the U.S. population is increasing alongside a growing burden of age-related cardiovascular disease.
View Article and Find Full Text PDFDiabetic cardiomyopathy (DCM) is a growing clinical entity and major health burden characterized by comorbid diabetes mellitus and heart failure. DCM has been commonly associated with impaired function of the left ventricle (LV); however, DCM likely also occurs in the right ventricle (RV) which has distinct physiology and pathophysiology from the LV. RV dysfunction is the strongest determinant of mortality in several clinical contexts yet remains poorly studied in diabetes.
View Article and Find Full Text PDFComplexin determines magnitude and kinetics of synchronized secretion, but the underlying molecular mechanisms remained unclear. Here, we show that the hydrophobic face of the amphipathic helix at the C-terminus of Complexin II (CpxII, amino acids 115-134) binds to fusion-promoting SNARE proteins, prevents premature secretion, and allows vesicles to accumulate in a release-ready state in mouse chromaffin cells. Specifically, we demonstrate that an unrelated amphipathic helix functionally substitutes for the C-terminal domain (CTD) of CpxII and that amino acid substitutions on the hydrophobic side compromise the arrest of the pre-fusion intermediate.
View Article and Find Full Text PDFArticle Synopsis
- * Research in mice shows that the absence of certain TRPC channel proteins (specifically TRPC5) leads to a significant reduction in adrenaline release during insulin-induced hypoglycemia.
- * There is a newly identified signaling pathway where specific receptor activation leads to TRPC5 channel stimulation, impacting adrenaline secretion, with similar plasma metabolite changes noted in both TRPC5-deficient mice and HAAF patients.
Article Synopsis
- Aging is a key risk factor for heart disease, but research shows that the right ventricle (RV) ages differently than the left ventricle (LV), with unique structural and functional changes.
- Researchers conducted a study using RNA sequencing to explore these differences in RV and LV from young and aged mice, revealing that while the LV typically experiences concentric remodeling and diastolic dysfunction, the aging RV shows eccentric remodeling, dilation, and impaired systolic function.
- The study identified unique molecular mechanisms of RV aging, highlighting specific genes and pathways that could guide future therapies, emphasizing the need for treatment approaches tailored to the distinct aging processes of the RV and LV.