Publications by authors named "D A Bruner"
Article Synopsis
- The NRG/RTOG 0436 study investigated whether adding cetuximab to chemoradiation for non-operative esophageal cancer would improve patient-reported outcomes (PROs), focusing on the FACT-Esophageal cancer subscale (ECS).
- The study was stopped early due to failing to meet overall survival (OS) targets; among 344 enrolled patients, those receiving CRT plus cetuximab showed less improvement in ECS compared to those receiving standard CRT alone (37% vs. 53%).
- Overall, the results indicated that adding cetuximab did not enhance PROs related to symptoms, swallowing, or eating, and there was no significant link between clinical complete
Cancer patients are commonly affected by fatigue. Herein, we sought to examine epigenetic modifications (i.e.
View Article and Find Full Text PDFIntroduction: Travel burden leads to worse cancer outcomes. Understanding travel burden and the level and types of travel support provided at large cancer centers is critical for developing systematic programs to alleviate travel burden. This study analyzed patients who received travel assistance, including their travel burden, types and amount of travel support received, and factors that influenced these outcomes.
View Article and Find Full Text PDFJCO NRG Oncology RTOG 0415 is a randomized phase III noninferiority (NI) clinical trial comparing conventional fractionation (73.8 Gy in 41 fractions) radiotherapy (C-RT) with hypofractionation (H-RT; 70 Gy in 28) in patients with low-risk prostate cancer. The study included 1,092 protocol-eligible patients initially reported in 2016 with a median follow-up of 5.
View Article and Find Full Text PDFPurpose: To update the ASCO guideline on the management of cancer-related fatigue (CRF) in adult survivors of cancer.
Methods: A multidisciplinary panel of medical oncology, geriatric oncology, internal medicine, psychology, psychiatry, exercise oncology, integrative medicine, behavioral oncology, nursing, and advocacy experts was convened. Guideline development involved a systematic literature review of randomized controlled trials (RCTs) published in 2013-2023.