[Myelotoxicity of a plant cytostatic preparation etoposide].

The myelotoxicity and the hemopoiesis recovery effect of etoposide, an antitumor preparation of the podophyllotoxin group, were experimentally studied on mice. It was found that the main role in the hemopoiesis recovery after etoposide administration is related to accelerated proliferation and increased differentiation of the hemopoietic precursor cells.

Compensatory reactions during impairment of granulocytic stem in patients with lung cancer receiving antitumor chemotherapy.

We compared changes in the granulocytic hemopoietic stem in patients with stage III-IV lung cancer receiving cytostatic therapy by the original CVC and standard CAM schemes. In patients treated with the CVC regimen, the granulocytic hemopoietic stem possessed more potent compensatory capacities.

[Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy].

Cytostatic therapy of patients with lung cancer is attended with decrease in the relative number of T-lymphocytes and their theophylline-resistant population. Patients who were given SB showed a tendency towards increase of these parameters during antitumor chemotherapy. The immunoregulation index (IRI) in this case was approximately twice the background values during the whole period of investigation.

[Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patents with lung cancer].

Hemopoiesis was studied in 88 patients with lung cancer during antitumor chemotherapy and its combination with a dry SB extract. Administration of the plant preparation was accompanied with hemopoiesis stimulation, intensification of bone-marrow erythro- and granulocytopoiesis and increase in the content of circulating precursors of the type of erythroid and granulomonocytic colony-forming units.

[The stimulating effect of sialic acid on the processes of postradiation hemopoietic regeneration].

The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.