Oncogenomics.

The rapid developments in the field of genomics and proteomics are expected to lead to a further increase in the potential for early diagnosis, the fine-tuning of prognostic features of specific tumors and the detection of cancer predisposition. Oncogenomics has identified new drug targets for genotype-specific treatments and provided strategies to validate these targets and to develop drugs. With the potential need to stratify patients by genotype, clinical testing of targeted drugs has become more complicated while expectations of patients, investors, and funding agencies have become accelerated.

Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats.

Cisplatin is an active cytotoxic agent that has proved to be successful in the treatment of various types of solid tumors. The drug-induced nephrotoxicity has been very well documented in clinical oncology. However, hepatotoxicity has been rarely characterized and paid attention to, and is the least studied.

Fine structure of prolactin cell of female albino rat as affected by some antifertility drugs--a comparative electron microscopic study.

One antioestrogenic compound as well as some antifertility drugs have been administered to female albino rats over a period of six months to study their long term effects on fine structures in PRL cell. Almost in all the cases, the dynamics of hormone synthesis and secretion have been affected. Fine structure is suggestive of activation of synthetic machinery of the cell.

The endotheliochorial interhemal membrane of the Indian musk shrew, Suncus murinus: an ultrastructural study.

Even though the chorioallantoic placenta of Suncus has been previously investigated with light and electron microscopy, controversies related to its structure still remain. To resolve these, Suncus murinus placentae from several (early and late limb bud, advanced pregnancy, and full term) were examined by electron microscopy. The interhemal membrane of Suncus comprises a maternal endothelium with basal lamina, syncytial trophoblast with its basal lamina, fetal mesenchyme, and fetal capillary endothelium.

Effect of depot medroxyprogesterone acetate and testosterone ananthate on the testis of albino rats: ultrastructural and biochemical studies.

Male albino rats were treated with depot medroxyprogesterone acetate (1 mg/animal/day) + testosterone ananthate (100 micrograms/100 g body weight/day) for 30 and 60 days. After 30 days of treatment, all the testicular enzymes like beta-glucuronidase, hyaluronidase, sorbitol dehydrogenase, lactate dehydrogenase, acid and alkaline phosphatase, registered non-significant decrease in their values. Fifty percent of the treated animals achieved sterility after 30 days of treatment.