Publications by authors named "D A Balbuena"
Article Synopsis
- The cardiac electrical impulse relies on the balance of ionic currents in heart cells, specifically the inwardly rectifying potassium current (I(K1)) and sodium current (I(Na)), which are crucial for maintaining the resting membrane potential and facilitating rapid depolarization during action potentials.
- The interaction between I(K1) and I(Na) influences cell excitability and can lead to abnormal heart rhythms, with significant implications for heart health.
- Using various experimental techniques, researchers found that these ionic currents reciprocally modulate the expression of their respective channel proteins (Kir2.1 and Na(V)1.5) through a complex involving the protein SAP97, which affects how well the heart can maintain its rhythm.
Causes of death during tuberculosis treatment in Tomsk Oblast, Russia.
Int J Tuberc Lung Dis
August 2006
Setting: Tuberculosis (TB) incidence and mortality in Russia have risen dramatically over the past 15 years.
Objective: To identify risk factors and causes of death among TB patients in Russia.
Design: A retrospective study conducted to determine the risk factors and causes of death in patients receiving TB therapy in Tomsk, Siberia.
We report on the production of hydrocortisone, the major adrenal glucocorticoid of mammals and an important intermediate of steroidal drug synthesis, from a simple carbon source by recombinant Saccharomyces cerevisiae strains. An artificial and fully self-sufficient biosynthetic pathway involving 13 engineered genes was assembled and expressed in a single yeast strain. Endogenous sterol biosynthesis was rerouted to produce compatible sterols to serve as substrates for the heterologous part of the pathway.
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