ZYG-12/Hook's dual role as a dynein adaptor for early endosomes and nuclei is regulated by alternative splicing of its cargo binding domain.

The microtubule motor cytoplasmic dynein-1 transports and positions various organelles, but the molecular basis of this functional diversity is not fully understood. Cargo adaptors of the Hook protein family recruit dynein to early endosomes (EE) in fungi and human cells by forming the FTS-Hook-FHIP (FHF) complex. By contrast, the Hook homolog ZYG-12 recruits dynein to the nuclear envelope (NE) in the meiotic gonad and mitotic early embryo by forming a Linker of Nucleoskeleton and Cytoskeleton (LINC) complex.

Thermal Manipulation During the Embryonic Stage and the Post-Hatch Characteristics of Broiler Chickens.

The objective of this study was to evaluate the influence of thermal manipulation during incubation on the hatchability, the performance, the carcass characteristics, the intestinal villi, the nutrient metabolizability, and some physiological parameters in broiler chickens. Ross eggs were randomly distributed into four commercial automatic incubators. The treatments were as follows: incubator kept at 37.

Epidemiological and Radiomorphometric Aspects of the Accessory Mental Foramen in Brazilian Individuals: An Analysis by Cone Beam Computed Tomography.

Background: The accessory mental foramen is characterized by small foramina in the surrounding area of the mental foramen with communication with the mandibular canal. The aim of this research was to evaluate epidemiological and radiomorphometric aspects of the accessory mental foramen (AMF) using cone beam computed tomography (CBCT) in Brazilian individuals.

Material And Methods: This was a cross-sectional, quantitative, retrospective descriptive study with 250 CBCT scans of dentate individuals in the anterior mandibular region, aged between 18 and 69 years.

"Quality over quantity:" smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor.

Introduction: MRI-guided focused ultrasound (MRgFUS) thalamotomy of the nucleus ventralis intermedius (VIM) has emerged as a powerful and safe treatment modality for refractory essential tremor. While the efficacy of this technique has been extensively described, much remains unclear about how to optimize MRgFUS for patient quality of life (QoL), which may depend as much on a patient's adverse effect profile as on the magnitude of tremor suppression. Diffusion tensor imaging (DTI) has been used to help guide targeting strategies but can pose certain challenges for scalability.