Hydrologic balance and inundation dynamics of Southeast Asia's largest inland lake altered by hydropower dams in the Mekong River basin.

Inland lakes have been increasingly impacted by climate change and human activities, leading to unprecedented environmental consequences. Among many rapidly changing lakes is the Tonlé Sap Lake (TSL) in Cambodia-Southeast Asia's largest inland lake-which is under growing threats from altered flows and inundation dynamics due to compounding effects of climate change and dam construction in the Mekong River basin (MRB). While previous studies have examined the potential causes of recent changes in open water areas, a mechanistic quantification of the lake's shifting hydrologic balance and inundation dynamics due to natural climate variability and dam operations is lacking.

Cost-Effectiveness of Multitarget Stool DNA Testing vs Colonoscopy or Fecal Immunochemical Testing for Colorectal Cancer Screening in Alaska Native People.

Objective: To estimate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska Native adults.

Patients And Methods: A Markov model was used to evaluate the 3 screening test effects over 40 years. Outcomes included colorectal cancer (CRC) incidence and mortality, costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs).

High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9.

Purpose: We have previously identified tissue methylated DNA markers (MDMs) associated with pancreatic ductal adenocarcinoma (PDAC). In this case-control study, we aimed to assess the diagnostic performance of plasma MDMs for PDAC.

Experimental Design: Thirteen MDMs (, and ) were identified on the basis of selection criteria applied to results of prior tissue experiments and assays were optimized in plasma.