Publications by authors named "D'incan M"
Article Synopsis
- Primitive cutaneous T-cell lymphomas are skin-specific lymphomas, distinct from systemic lymphomas affecting the skin.
- The most common types include mycosis fungoides, CD30+ lymphoproliferations, and erythrodermic T-cell lymphomas, with several rarer forms also identified.
- Diagnosis relies on clinical skin exams and biopsies, enhanced by molecular genetics, while treatments are categorized into five main types, including skin therapies and immunotherapies.
Background: Mycosis fungoides (MF) usually has an indolent course. However, some patients develop more aggressive disease and few prognostic parameters have been identified. Isolated cases of pustular MF (pMF) suggest an unfavourable prognosis.
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- Sézary syndrome is a rare and deadly skin cancer, and this study looked into the survival rates and factors affecting outcomes, particularly focusing on the treatment mogamulizumab.
- *The research analyzed data from 339 patients diagnosed between 2000 and 2020 across Europe, highlighting that age over 80 and large-cell transformation worsened survival rates.
- *Results indicated that patients treated with mogamulizumab had significantly lower mortality rates, suggesting it is an effective treatment option for Sézary syndrome.
Article Synopsis
- The Ritux 3 trial showed that rituximab is effective and safe as a first-line treatment for pemphigus, although long-term follow-up data was previously lacking.!* -
- This 7-year follow-up study evaluated the long-term outcomes for patients treated with rituximab alongside prednisone versus those treated with prednisone alone, focusing on disease-free survival and relapse rates.!* -
- Results indicated that 93% of patients in the rituximab group achieved complete remission without corticosteroids, showing significantly higher disease-free survival and lower relapse rates compared to the prednisone-only group.!*
Background: Efficacy and safety of mogamulizumab, a monoclonal antibody directed against C-C chemokine receptor 4, were demonstrated in a previous multinational clinical trial conducted in patients with previously treated cutaneous T-cell lymphoma (CTCL): Sézary syndrome (SS) or Mycosis Fungoides (MF).
Objectives: The real-world French OMEGA study aimed to describe effectiveness and tolerability of mogamulizumab in adult patients with CTCL, overall and according to the disease (SS or MF).
Methods: In this retrospective study, patients treated with mogamulizumab for SS or MF were included from 14 French expert centres.
Background: Advanced-stage cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and fatal diseases. Case series have suggested that allogeneic haematopoietic stem cell transplantation (HSCT) might improve the prognosis of advanced-stage CTCLs. The objective of this study was to investigate the effect of allogeneic HSCT compared with non-HSCT therapy on the outcome of individuals with advanced-stage CTCLs.
View Article and Find Full Text PDFBackground: Skin-restricted lupus is a chronic inflammatory disease associated with high rates of depression and anxiety disorders. Patients without psychiatric disorders can experience anxiety and depressive symptoms at a subclinical level, which could be risk factors for progression towards psychiatric disorders. It was decided, therefore, to investigate the presence of specific symptoms in skin-restricted lupus patients without axis I psychiatric disorders and their impact on the occurrence of axis I psychiatric disorders during the study follow-up.
View Article and Find Full Text PDFBackground: Adverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet.
Objectives: To assess a potential relationship between the occurrence of APO and the serum value of anti-BP180 antibodies at the time of PG diagnosis.
Article Synopsis
- * Utilizing a comprehensive meta-analysis of 37 articles and data from multiple sources, researchers focused on distinguishing between specific diagnoses and general symptoms.
- * Results indicate that the prevalence of depressive disorders (9%) and unspecified anxiety disorders (13%) in patients with AA is significantly higher than in the general population, emphasizing the need for targeted mental health support for these patients.
Background: Our objective was to describe the clinical, histological characteristics, and disease outcome of a cohort of mycosis fungoides (MF) diagnosed during childhood including disease status at adulthood.
Methods: This is a retrospective multicentre survey of patients aged under 18 years at diagnosis with histologically confirmed MF. Patients' clinical and histological characteristics, treatments, and disease outcome (for patients followed for more than 12 months) were analysed.
Article Synopsis
- * The analysis included a total of 101 relevant articles, revealing a 34% prevalence of anxiety symptoms among psoriasis patients and a positive correlation between psoriasis and generalized anxiety symptoms, with significant odds ratios indicating higher risk levels.
- * The findings highlight the need for routine screening for anxiety disorders in psoriasis patients, similar to existing recommendations for depression, and emphasize the importance of mental health referrals for appropriate care.
Background: Benzamide-based radioligands targeting melanin were first developed for imaging melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT). [I]ICF01012 presents a highly favorable pharmacokinetics profile in vivo for therapy. Tumour growth reduction and increase survival have been established in preclinical models of melanoma.
View Article and Find Full Text PDFPalmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort.
J Eur Acad Dermatol Venereol
September 2022
Background: Acral pustular disease within the pustular psoriasis/psoriasis-like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP.
Objectives: We aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort.
Article Synopsis
- A study found that high levels of anti-BP180 antibodies and positive immunofluorescence tests (ITs) can predict relapses in bullous pemphigoid patients after stopping treatment.
- The research evaluated how using IT results to decide when to stop treatment affected relapse rates at 3 and 6 months post-treatment.
- The results showed no significant difference in relapse rates among patients whose treatment cessation was based on IT results versus those who were not, suggesting that clinical decisions may be equally effective.
Background: European guidelines propose a 0·5 mg kg per day dose of oral prednisone as initial treatment for bullous pemphigoid (BP). We assessed the safety and efficacy of this regimen depending on BP extent and general condition of the patients.
Methods: In a prospective international study, we consecutively included all patients diagnosed with BP.
Purpose: To assess the efficiency of targeted radionuclide therapy (TRT), alone or in combination with MEK inhibitors (MEKi), in melanomas harboring constitutive MAPK/ERK activation responsible for tumor radioresistance.
Methods: For TRT, we used a melanin radiotracer ([I]ICF01012) currently in phase 1 clinical trial (NCT03784625). TRT alone or combined with MEKi was evaluated in three-dimensional melanoma spheroid models of human BRAF SK-MEL-3, murine NRAS 1007, and WT B16F10 melanomas.
Background: Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T-cell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe and about potential changes over time.
Objectives: The aim of this retrospective study was to analyse the frequency of PCLs in the French Cutaneous Lymphoma Registry (GFELC) and to describe the demography of patients.
Article Synopsis
- * A systematic review found a significant prevalence of depression (27%) and anxiety (28%) among patients with lichen planus, with variations possibly due to geographical and methodological differences.
- * The findings indicate a strong statistical relationship (odds ratio 3.79 for depression and 2.54 for anxiety) and highlight the importance of screening and potential psychiatric referrals for affected patients.
Recent outbreak of chilblain-like lesions is not directly related to SARS-CoV-2 infection.
J Eur Acad Dermatol Venereol
November 2020
In line with the ongoing phase I trial (NCT03784625) dedicated to melanoma targeted radionuclide therapy (TRT), we explore the interplay between immune system and the melanin ligand [I]ICF01012 alone or combined with immunotherapy (immune checkpoint inhibitors, ICI) in preclinical models. Here we demonstrate that [I]ICF01012 induces immunogenic cell death, characterized by a significant increase in cell surface-exposed annexin A1 and calreticulin. Additionally, [I]ICF01012 increases survival in immunocompetent mice, compared to immunocompromised (29 vs.
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- Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a newly identified condition classified by the WHO in 2017, characterized by a slow-growing, localized skin lesion primarily in adults (mean age 59).
- In a study of 60 patients, the majority presented with nodules on the head and neck, and 31.9% experienced spontaneous regression, indicating a generally indolent disease course over an average follow-up of 16.6 months.
- Histologically, PCSMLPD often shows extensive nodular or diffuse infiltrates in the dermis and varying patterns of T-follicular helper lineage markers, but commonly